Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3
نویسندگان
چکیده
منابع مشابه
Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3
Acid-sensing ion channels (ASICs) ASIC3 expressed mainly in peripheral sensory neurons play an important role in pain perception and inflammation development. In response to acidic stimuli, they can generate a unique biphasic current. At physiological pH 7.4, human ASIC3 isoform (hASIC3) is desensitized and able to generate only a sustained current. We found endogenous isoquinoline alkaloids (E...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2017
ISSN: 1662-5099
DOI: 10.3389/fnmol.2017.00282